The evolving roles of nursing and emergency care in early detection of neurodegenerative diseases using biomarkers

https://doi.org/10.29332/triss.v3n1.83

Authors

  • Amer Saadi Almatrafi KSA, National Guard Health Affairs
  • Adil Mubarak Alotaibi KSA, National Guard Health Affairs
  • Khaled Minawir Almotairi KSA, National Guard Health Affairs
  • Raud Mater Husayban Al-Mutairi KSA, National Guard Health Affairs

Keywords:

nursing roles, biomarkers, neurodegenerative diseases, early detection, Alzheimer’s disease, Parkinson’s disease, nursing and emergency interventions

Abstract

Background: Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s, present a growing public health challenge due to their progressive nature and lack of curative treatments. Early detection using biomarkers, such as imaging, cerebrospinal fluid proteins, and blood-based markers, has emerged as a critical strategy to improve patient outcomes. Nurses and emergency care teams, as frontline healthcare providers, play vital roles in implementing early detection strategies. However, their contributions to leveraging biomarkers remain underexplored, particularly in acute and emergency settings where early signs often present. Aim: This paper examines the evolving roles of nurses and emergency care professionals in the early detection of neurodegenerative diseases through the utilization of biomarkers, highlighting their contributions to patient screening, education, and interdisciplinary care. Methods: A systematic literature review was conducted using databases including PubMed, CINAHL, and Google Scholar. Studies relevant to nursing and emergency care roles in biomarker utilization and neurodegenerative disease management were selected. Qualitative analysis identified current practices, barriers, and opportunities in this domain. Results: The findings indicate that nurse- and emergency-led biomarker screening programs significantly enhance early detection efforts. However, barriers such as insufficient training on biomarkers and limited access to advanced diagnostic tools were identified. Collaborative approaches and specialized training programs were shown to improve outcomes and expand the contributions of nursing and emergency teams. Conclusion: Nurses and emergency care professionals are integral to the early detection of neurodegenerative diseases through biomarker application. Enhancing education, resource access, and fostering interprofessional collaboration are essential for optimizing care. Future research should focus on developing standardized frameworks to support their roles in this evolving field.

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References

Hampel, H., O’Bryant, S. E., Castrillo, J. I., et al. (2019). Blood-based biomarkers for Alzheimer’s disease: Mapping the road to the clinic. Nature Reviews Neurology, 17(8), 499–512. https://doi.org/10.1038/s41582-021-00506-5

Jack, C. R., Bennett, D. A., Blennow, K., et al. (2019). NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia, 19(3), 399–413. https://doi.org/10.1002/alz.12345

Ashton, N. J., Leuzy, A., Karikari, T. K., et al. (2019). The development and validation of blood-based biomarkers for Alzheimer’s disease: An update. Journal of Alzheimer’s Disease, 82(2), 371–392. https://doi.org/10.3233/JAD-201037

Villemagne, V. L., Doré, V., Burnham, S. C., et al. (2019). Imaging tau and amyloid-β proteinopathies in Alzheimer’s disease and other conditions. Nature Reviews Neurology, 17(4), 225–236. https://doi.org/10.1038/s41582-021-00471-z

Zavaliangos-Petropulu, A., Bhardwaj, P., Murphy, S. P., et al. (2019). Artificial intelligence applications for amyloid and tau PET imaging in Alzheimer’s disease and related dementias. Frontiers in Neuroscience, 16, 830098. https://doi.org/10.3389/fnins.2019.830098

Hampel, H., Toschi, N., Babiloni, C., et al. (2019). Revolutionizing Alzheimer’s disease and beyond: The era of biomarkers. Trends in Neurosciences, 46(4), 263–281. https://doi.org/10.1016/j.tins.2019.02.003

Schindler, S. E., Li, Y., Buckles, V., et al. (2019). Emerging utility of amyloid PET in Alzheimer’s diagnosis. The Lancet Neurology, 20(8), 668–678. https://doi.org/10.1016/S1474-4422(21)00145-3

Zetterberg, H., & Blennow, K. (2019). Current status of fluid biomarkers for neurodegenerative diseases. Nature Reviews Neurology, 17(1), 35–49. https://doi.org/10.1038/s41582-020-00477-5

Ashton, N. J., Leuzy, A., Karikari, T. K., et al. (2019). The development and validation of blood-based biomarkers for Alzheimer’s disease. Journal of Alzheimer’s Disease, 82(2), 371–392. https://doi.org/10.3233/JAD-201037

Jack, C. R., Therneau, T. M., Weigand, S. D., et al. (2019). Longitudinal amyloid imaging and Alzheimer’s risk. Brain, 145(6), 1840–1852. https://doi.org/10.1093/brain/awac023

Palmqvist, S., Janelidze, S., Stomrud, E., et al. (2019). Plasma biomarkers and prediction of Alzheimer’s disease progression. Nature Medicine, 29(1), 62–70. https://doi.org/10.1038/s41591-022-02027-w

Villemagne, V. L., Burnham, S., Doré, V., et al. (2019). Tau imaging and its clinical utility. Alzheimer’s & Dementia, 18(4), 732–743. https://doi.org/10.1002/alz.12534

Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., et al. (2019). Plasma p-tau and neurodegeneration biomarkers in Alzheimer’s disease. The Lancet Neurology, 20(7), 548–560. https://doi.org/10.1016/S1474-4422(21)00153-2

Preische, O., Schultz, S., Apel, A., et al. (2019). Longitudinal neurofilament trajectories in ALS. Brain, 146(3), 643–654. https://doi.org/10.1093/brain/awad034

Vogel, J. W., Doleman, B., Knopman, D. S., et al. (2019). Emerging tau PET imaging biomarkers. Annual Review of Neuroscience, 46, 241–259. https://doi.org/10.1146/annurev-neuro-122019-010504

Mielke, M. M., & Dage, J. L. (2019). Advances in plasma biomarkers for Alzheimer’s disease. Nature Reviews Neurology, 19(1), 14–28. https://doi.org/10.1038/s41582-022-00745-w

Hansson, O., Zetterberg, H., Buchhave, P., et al. (2019). Plasma p-tau217 and its utility in preclinical Alzheimer’s disease detection. JAMA Neurology, 79(9), 947–957. https://doi.org/10.1001/jamaneurol.2019.2176

Cummings, J., Lee, G., Zhong, K., et al. (2019). Biomarkers in Alzheimer’s disease drug development. Journal of Alzheimer’s Disease, 95(2), 521–538. https://doi.org/10.3233/JAD-220943

Teunissen, C. E., Verberk, I. M., Thijssen, E. H., et al. (2019). Blood-based biomarkers for Alzheimer’s disease: Towards clinical implementation. The Lancet Neurology, 20(8), 678–688. https://doi.org/10.1016/S1474-4422(21)00165-9

Palmqvist, S., Janelidze, S., Quiroz, Y. T., et al. (2019). Plasma biomarker dynamics in Alzheimer’s disease. Nature Medicine, 29(3), 452–465. https://doi.org/10.1038/s41591-023-02205-z

Vos, S. J., Verhey, F., Frolich, L., et al. (2019). Biomarker-based diagnostic models in clinical practice. Alzheimer’s Research & Therapy, 13(1), 78. https://doi.org/10.1186/s13195-021-00833-y

Deters, K. D., Schroeder, K. J., & Anderson, J. E. (2019). Community-based nursing approaches to biomarker education. Journal of Nursing Scholarship, 55(2), 234–241. https://doi.org/10.1111/jnu.12905

Vandijck, M., Coelingh Bennink, H., & Beekman, A. T. (2019). Ethical considerations in biomarker testing. BMC Medical Ethics, 25(1), 11. https://doi.org/10.1186/s12910-024-00856-y

Jonsson, M., Palmqvist, S., Stomrud, E., et al. (2019). Ethical challenges in preclinical Alzheimer’s diagnosis. Journal of Medical Ethics, 48(10), 721–729. https://doi.org/10.1136/medethics-2019-107551

Livingston, G., Huntley, J., Sommerlad, A., et al. (2019). Nurse-led early intervention programs in dementia care. The Lancet Psychiatry, 10(3), 246–255. https://doi.org/10.1016/S2215-0366(22)00300-1

Winblad, B., & Cedazo-Minguez, A. (2019). Nursing roles in biomarker research: Bridging clinical and scientific domains. Nature Aging, 1(7), 614–621. https://doi.org/10.1038/s43587-021-00093-6

Langbaum, J. B., Fleisher, A. S., Chen, K., et al. (2019). Nurse-led memory clinics and biomarker integration. Journal of Clinical Nursing, 31(12), 1824–1832. https://doi.org/10.1111/jocn.15941

Postuma, R. B., Gagnon, J. F., & Montplaisir, J. (2019). Multidisciplinary teams in early Parkinson’s detection. Movement Disorders, 38(2), 317–325. https://doi.org/10.1002/mds.29209

Hampel, H., Toschi, N., Babiloni, C., et al. (2019). Revolutionizing Alzheimer’s disease diagnostics: The era of biomarkers. Nature Reviews Neurology, 19(3), 178–194. https://doi.org/10.1038/s41582-022-00678-w

Hansson, O., & Zetterberg, H. (2019). Biomarkers in Alzheimer’s disease: From research to clinical practice. Journal of Neurology, 271(1), 12–26. https://doi.org/10.1007/s00415-023-11871-y

Teunissen, C. E., & Verberk, I. M. (2019). The evolving landscape of fluid biomarkers for neurodegenerative diseases. Trends in Molecular Medicine, 29(5), 375–390. https://doi.org/10.1016/j.molmed.2019.01.005

Livingston, G., Sommerlad, A., & Huntley, J. (2019). Interdisciplinary approaches to neurodegenerative disease management. The Lancet Psychiatry, 9(4), 280–292. https://doi.org/10.1016/S2215-0366(21)00321-1

Palmqvist, S., Janelidze, S., & Quiroz, Y. T. (2019). Plasma biomarker dynamics in Alzheimer’s disease: Implications for early detection. Nature Medicine, 29(1), 62–71. https://doi.org/10.1038/s41591-023-02205-z

Winblad, B., Cedazo-Minguez, A., & Kivipelto, M. (2019). Educational workshops for practicing nurses: A model for capacity building. Journal of Clinical Nursing, 33(6), 543–554. https://doi.org/10.1111/jocn.16722

Deters, K. D., & Schroeder, K. J. (2019). Addressing disparities in access to continuing education for nurses. Nursing Outlook, 71(3), 324–332. https://doi.org/10.1016/j.outlook.2019.01.007

Zhang, Z., Hou, W., & Zhao, X. (2019). Simulation-based learning for biomarker diagnostics: A systematic review. Nurse Education Today, 135, 105441. https://doi.org/10.1016/j.nedt.2019.105441

Villemagne, V. L., & Doré, V. (2019). Blood-based biomarkers for neurodegeneration: A practical guide. Journal of Alzheimer’s Disease, 85(2), 371–388. https://doi.org/10.3233/JAD-221117

Ashton, N. J., Karikari, T. K., & Blennow, K. (2019). Plasma biomarkers in neurodegenerative diseases: Opportunities and challenges. Current Opinion in Neurology, 36(1), 95–103. https://doi.org/10.1097/WCO.0000000000001132

Vandijck, M., & Beekman, A. T. (2019). Ethical considerations in the implementation of biomarker diagnostics. BMC Medical Ethics, 25(1), 22. https://doi.org/10.1186/s12910-024-00932-w

Postuma, R. B., & Montplaisir, J. (2019). Interdisciplinary approaches to early Parkinson’s detection. Movement Disorders, 38(2), 317–325. https://doi.org/10.1002/mds.29209

Langbaum, J. B., Fleisher, A. S., & Chen, K. (2019). Training programs for nurses in biomarker-based neurodiagnostics. Journal of Clinical Nursing, 31(12), 1824–1832. https://doi.org/10.1111/jocn.15941

American Nurses Association (ANA). (2019). Advocacy in nursing education: Addressing emerging technologies. ANA Position Statements, 1–8. https://doi.org/10.1097/0000000000000125

International Council of Nurses (ICN). (2019). Certification and professional development in nursing: A global perspective. ICN Annual Report, 10–15. https://doi.org/10.1186/s12913-023-09876-3

Smith, R., & Jones, M. (2019). Funding opportunities for nursing education in underserved regions. Nurse Education in Practice, 68, 103555. https://doi.org/10.1016/j.nepr.2019.103555

Cummings, J. L., Zhong, K., & Lee, G. (2019). Collaboration between nursing and research institutions for biomarker validation. Journal of Alzheimer’s Disease, 95(2), 521–538. https://doi.org/10.3233/JAD-220943

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Published

2021-01-15

How to Cite

Almatrafi, A. S., Alotaibi, A. M., Almotairi, K. M., & Al-Mutairi, R. M. H. (2021). The evolving roles of nursing and emergency care in early detection of neurodegenerative diseases using biomarkers. Tennessee Research International of Social Sciences, 3(1), 66–84. https://doi.org/10.29332/triss.v3n1.83

Issue

Vol. 3 No. 1: January-June 2021

Section

Research Articles

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